eTOPIX_New LAG-3 Ligand FGL1 and other Immuno-Oncology Reagents from AdipoGen Life Sciences

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eTOPIX

The LAG-3 Immune Checkpoint

FGL1 - New Major LAG-3 Ligand
  • Fibrinogen-like Protein 1 (FGL1), a molecule secreted by the liver and pancreas, is a major ligand of LAG-3.
  • FGL1 binding to LAG-3 inhibits T cell response.
  • FGL1 is upregulated in human cancers. High plasma FGL1 levels are associated with poor clinical outcome in patients treated with anti-PD1 therapy.


 
LAG-3 Pathway
 

NEW FGL1 Proteins 
Fc (human):FGL1 (mouse) (rec.)
Fc (human):FGL1 (human) (rec.)
FGL1 (human) (rec.) (His)

AdipoGen Life Sciences developed new FGL1 proteins for LAG-3 and Immuno-Oncology Research. Fc (human):FGL1 (mouse) (rec.) (Prod. No. AG-40B-0185), Fc (human):FGL1 (human) (rec.) (Prod. No. AG-40B-0184) and FGL1 (human) (rec.) (His) (Prod. No. AG-40B-0186) are all produced in HEK 293 cells. The Fc-chimeric proteins are both produced as dimeric proteins, while the His-tagged protein is a monomeric construct. Low endotoxin levels and in-house performed binding studies on LAG-3 proteins make these new proteins valuable tools to study LAG-3 and its antitumor activity. Biological activity studies of these FGL1 proteins are ongoing.

Inquire for attractive BULK prices for extensive studies.
 

Potent LAG-3 Recombinant Protein
LAG-3 (mouse):Fc (mouse) (rec.)

The Fc-chimeric protein LAG-3 (mouse):Fc (mouse) (rec.) (Prod. No. AG-40B-0039) binds to human and mouse MHC class II. This protein induces maturation of mouse dendritic cells in vitro. It induces CD4 and CD8 antigen-specific T cells responses when co-injected in mice, together with the antigen. This protein has been produced in CHO cells as a high purity and low endotoxin research tool.

Inquire for attractive BULK prices for extensive studies.
 


COMING SOON: High Affinity Mouse LAG-3:COMP Protein
 



Standard LAG-3 Blocking Antibody
anti-LAG-3 (human), mAb (blocking) (17B4)

AdipoGen Life Sciences' anti-LAG-3 (human), mAb (blocking) (17B4) (Prod. No. AG-20B-0012) is a monoclonal antibody that recognizes human LAG-3 and works specifically in ICC, IHC (frozen sections), IP, WB and Functional Application. The antibody inhibits LAG-3 and MHC class II interactions. Especially the IHC competence makes this antibody a valuable research tool in human studies.

Inquire for attractive BULK prices for extensive studies.


Also available: 
anti-LAG-3, mAb (blocking) (11E3)
(Prod. No. AG-20B-0011)
anti-LAG-3 (human), mAb (AG-IHC103) (Prod. No. AG-20B-6023)
 
Discover More LAG-3 Reagents

Select Your Immune Checkpoint Pathway of Interest for a Panel of Products
 
PD-1 / PD-1L Pathway
ICOS / ICOSL Pathway 
TIM-3 / Galectin-9 Pathway
CD137 / CD137L Pathway

GITR / GITRL Pathway
CD40 / CD40L Pathway
Butyrophilin-like Proteins             
CTLA-4 - CD80 - CD86 - CD28 Network
LAG-3 - MHC - TCR Pathway
TIGIT - CD155 - CD112 - CD226 Network

OX40 / OX40L Pathway
HVEM - BTLA - LIGHT - CD160 Network
New B7 Family Members:

B7-H3, B7-H4, B7-H5 [VISTA], B7-H6
 
 
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Key Research Areas:
INFLAMMASOMES | INFLAMMATION
CANCER | OBESITY & DIABETES 
INNATE IMMUNITY | STEM CELL BIOLOGY
IMMUNO-ONCOLOGY | NOTCH SIGNALING

IMMUNOMETABOLISM
Product Groups:
ELISA KITS | ANTIBODIES
PROTEINS | SMALL MOLECULES
FLUORESCENT DYES & PROBES

RARE ANTIBIOTICS
 
 
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Products are for research use only. Not for human therapeutics or diagnostics use.