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AdipoGen E-News | September 2013 Special

Cytokines & Immune Checkpoint Regulators

Chimerigen offers a variety of non-lytic immunoglobulin-based chimeric cytokine fusion proteins, which possess both the biological functions of the cytokine moiety and a prolonged circulating half-life resul-ting from the Fc domain.


Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

IL-2 (human):Fc (human) (rec.) (non-lytic) BULK available!   CHI-HF-22002   50 µg
3 x 50 µg
IL-2 (mouse):Fc (mouse) (rec.) (non-lytic) BULK available!   CHI-MF-12002   10 µg
5 x 10 µg
IL-4 (human):Fc (human) (rec.) (non-lytic) BULK available!   CHI-HF-22004   10 µg
5 x 10 µg
IL-4 (mouse):Fc (mouse) (rec.) (non-lytic) BULK available!   CHI-MF-12004   10 µg
5 x 10 µg
IL-6 (human):Fc (human) (rec.) (non-lytic) BULK available!   CHI-HF-22006   50 µg
3 x 50 µg
IL-6 (mouse):Fc (mouse) (rec.) (non-lytic) BULK available!   CHI-MF-12006   50 µg
3 x 50 µg
IL-10 (human):Fc (human) (rec.) (non-lytic) BULK available!   CHI-HF-22010   10 µg
5 x 10 µg
IL-10 (mouse):Fc (mouse) (rec.) (non-lytic) BULK available!   CHI-MF-12010   10 µg
5 x 10 µg

IL-35 (human):Fc (human) (rec.)   CHI-HF-21035   25 µg
NEW IL-35 (mouse):Fc (human) (rec.)   CHI-MF-11135   5 µg

CTLA-4 [CD152]:Fc - enhances T cell cytotoxicity against tumor cells

CTLA-4 (human):Fc (human) (rec.)
BULK available!
  CHI-HF-210A4   100 µg
500 µg
1 mg
CTLA-4 (mouse):Fc (mouse) (rec.)
BULK available!
  CHI-MF-110A4   100 µg
500 µg
1 mg
CTLA-4 (mouse):Fc (mouse) (rec.) (non-lytic) BULK available!   CHI-MF-120A4   100 µg
500 µg
1 mg

PD-1 [CD279]:Fc - enhances T cell cytotoxicity against tumor cells

PD-1 (human):Fc (human) (rec.)
BULK available!
  CHI-HF-210PD1   100 µg
PD-1 (human):Fc (human) (rec.) (non-lytic) BULK available!   CHI-HF-220PD1   200 µg

ICOS [CD278]:Fc - required for optimal antitumor response mediated by anti-CTLA-4 treatment

ICOS (human):Fc (human) (rec.)   CHI-HF-210ICOS   25 µg
100 µg
ICOS (human):Fc (human) (rec.) (non-lytic)   CHI-HF-220ICOS   25 µg
100 µg

Tim-3:Fc - receptor blocking in combination with a second immune checkpoint inhibitor enhances antitumor immunity

Tim-3 (human):Fc (human) (rec.)   CHI-HF-210T3   100 µg
Tim-3 (mouse):Fc (human) (rec.)   CHI-MF-111T3   100 µg

Immune Checkpoint Ligand Proteins

B7-H4 (human):Fc (human) (rec.)   CHI-HF-210B7H4   100 µg
B7-H2 (mouse):Fc (mouse) (rec.)   CHI-MF-110B7H2   100 µg
PD-L1 (human):Fc (human) (rec.)   CHI-HF-210PDL1   100 µg
PD-L1 (human):Fc (human) (rec.) (non-lytic)   CHI-HF-220PDL1   100 µg
PD-L1 (mouse):Fc (mouse) (rec.)   CHI-MF-110PDL1   100 µg
PD-L1 (mouse):Fc (mouse) (rec.) (non-lytic)   CHI-MF-120PDL1   100 µg
PD-L2 (human):Fc (human) (rec.) (non-lytic)   CHI-HF-220PDL2   100 µg

Chimerigen Suppl. Catalog 2013

Check our Website www.adipogen.com for more Unique Reagents!

For Ordering please visit: www.adipogen.com
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