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AdipoGen E-News | February 2014

New Small Molecules, Rare Antibiotics & Unique Natural Products

Hedgehog Signaling | Obesity Research | H2S Pathway | ManRos Neurobiology Reagents | New Introductions

NEW Hedgehog Signaling Modulators

22-NHC . HCl Hedgehog signaling inhibitor AG-CR1-3523
22-NHC (inactive isomer) Control compound for 22-NHC AG-CR1-3524

22-NHC is an azasterol that blocks Hedgehog signaling by binding to the oxysterol-binding site of Smo.

Lit: Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling: D. Nedelcu, et al.; Nat. Chem. Biol. 9, 557 (2013)

Also available:
Panel of SAGs Cell permeable Smo agonists
GANT61 Cell permeable Gli antagonist AG-CR1-3561
SANT-2 Cell permeable Smo antagonist AG-CR1-3514
Cyclopamine Cell permeable Smo inhibitor AG-CN2-0028

NEW Obesity Research Small Molecules

AdipoRon Unique & potent AdipoR agonist AG-CR1-0154
Compound 112254 Unique AdipoR agonist AG-CR1-0155

LIT: A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity: M. Okada-Iwabu, et al.; Nature 503, 493 (2013) | Cell Biology. Ronning after the adiponectin receptors: W.L. Holland & P.E. Scherer; Science 342, 1460 (2013)

NEW H2S Detection Probe

7-Azido-4-methylcoumarin Selective H2S probe AG-CR1-3525

7-Azido-4-methylcoumarin (AzMC) is a highly sensitive and selective fluorogenic H2S probe. It can be used both to monitor enzymatic production of H2S in vitro and to visualize H2S in living cells. Useful for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. CBS, CGL and TS) and to identify inhibitors and activators in high-throughput screenings.

Lit: Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe: M.K. Thorson, et al.; Angew. Chem. Int. Ed. Engl. 52, 4641 (2013)

Also available:
H2S Donor 5a Cysteine-activated H2S donor AG-CR1-3510
GYY 4137 Water-soluble, slow-releasing H2S donor AG-CR1-3513

NEW Introductions & Highlights

Atpenin A5 Mitochondrial complex II inhibitor AG-CN2-0100
Benadrostin PARP inhibitor BVT-0079
Boromycin Boron-containing macrolide antibiotic AG-CN2-0166
Butyrolactone 3 Specific HAT Gcn5 inhibitor AG-CR1-3522
Lactacystin Potent 20S proteasome inhibitor AG-CN2-0104
Tripolin A Specific Aurora A kinase inhibitor AG-CR1-3520
Tripolin B Aurora A and B modulator AG-CR1-3521
Itaconic acid Modulator in innate immunity AG-CN2-0426

Comprehensive Panel of Manumycins
Manumycin A Potent rasfarnesyltransferase inhibitor BVT-0091
Manumycin B Apoptosis (caspase-1) inhibitor BVT-0264
Deoxymanumycin A Derivative of manumycin A BVT-0158
Dihydromanumycin A Derivative of manumycin A BVT-0414

NEW ManRos™ Neurobiology Reagents

Leucettine L41 Anti-Alzheimer's agent MR-C0023
Aftin-4 Alzheimer's disease accelerator MR-C0014
Aftin-5 Alzheimer's disease accelerator MR-C0015
(R)-Perharidine 1 CDK1/2/5/9 & CK1δ/ε inhibitor MR-C0013
(S)-Perharidine 1 CDK1/2/5/9 & DYRK1A inhibitor MR-C0012
BULK available for all products!

Bulk Commodities for Crystallography

n-Dodecyl-α-D-maltoside (ultrapure) Non-ionic detergent For crystallography AG-CC1-0006
n-Dodecyl-β-D-maltoside (ultrapure) Non-ionic detergent For crystallography AG-CC1-0004
n-Octyl-β-D-thioglucopyranoside (ultrapure) Non-ionic detergent For crystallography AG-CC1-0005

Check our Website www.adipogen.com for all or more Unique Reagents!

For Ordering please visit: www.adipogen.com
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