Small Molecule Highlights from AdipoGen Life Sciences

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picture          Immunometabolism &
         Advanced Inflammation

         Research Reagents


Small Molecules from the Manufacturer

Synthetic Molecules - Unique Natural Products - Rare Antibiotics


Small Molecules Highlights


 


HIGHLIGHTS  INFLAMMATION RESEARCH
 
NEW MCC950 . Na NLRP3 Inflammasome Inhibitor (In Vivo) AG-CR1-3615
NEW Myxochelin A 5-Lipoxygenase Inhibitor AG-CN2-0470
Monosodium Urate NLRP3 Inflammasome Activator AG-CR1-3950

Isoliquiritigenin Asc-oligomerization Inhibitor AG-CN2-0459

LIT: Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation: H. Honda, et al.; J. Leukoc. Biol. 96, 1087 (2014)

Isoliquiritgenin Structure



HIGHLIGHTS  METABOLIC RESEARCH
 
Linagliptin DPP4 Inhibitor AG-CR1-3618
Orlistat DAGLα Inhibitor AG-CN2-0050
Pyripyropene A ACAT2 Inhibitor AG-CN2-0106
Streptozotocin Diabetes Inducer AG-CN2-0046


HIGHLIGHTS  CANCER & IMMUNOLOGY RESEARCH
 
BLZ-945 CSF-1R Inhibitor AG-CR1-3609
Ibrutinib BTK Inhibitor AG-CR1-3620
Jasplakinolide F-actin Polymerization Inducer AG-CN2-0037

Salinosporamide A 20S Proteasome Inhibitor AG-CN2-0444

LIT: Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs: A. Obaidat, et al.; J. Pharmacol. Exp. Ther. 337, 479 (2011) | Molecular mechanisms of acquired proteasome inhibitor resistance: A.J. Kale & B.S. Moore; J. Med. Chem. 55, 10317 (2012) | Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib): D. Niewerth, et al.; Mol. Pharmacol. 86, 12 (2014)

Salinosporamide A Structure



HIGHLIGHTS  NEUROCHEMICALS
 
Tetrodotoxin VGSC Blocker AG-CN2-0452
Pellitorine Tingeling-inducing Agent AG-CN2-0009
New HDAC6 Inhibitors Tubastatin A AG-CR1-3900
Nexturastat A AG-CR1-3901
Nexturastat B AG-CR1-3902
ACY-775 AG-CR1-3903
DMAPB AG-CR1-3904
PMPH AG-CR1-3905
DABPH AG-CR1-3906
MBIMPH AG-CR1-3907
MBIMPH F-Analog 1 . HCl AG-CR1-3908
MBIMPH F-Analog 2 AG-CR1-3909

GV-58 N- & P/Q-type Ca2+ Channel Agonist MR-C0035

LIT: Synthesis and biological evaluation of a selective N- and P/Q-type Calcium channel agonist: M. Liang, et al.; ACS Med. Chem. Lett. 3, 985 (2012) | New calcium channel agonists as potential therapeutics in Lambert-Eaton myasthenic syndrome and other neuromuscular diseases: T.B. Tarr, et al.; Ann. N. Y. Acad. Sci. 1275, 85 (2012) | Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome: T.B. Tarr, et al.; J. Neurosci. 33, 10559 (2013)

Salinosporamide A Structure



COMMODITIES
 
Thapsigargin (high purity) Non-TPA/PMA Tumor Promoter AG-CN2-0003
IPTG (animal-free) β-Galactosidase Activity Inducer AG-CC1-0002
JC-10 (high purity) Improved MMP Probe AG-CR1-3600
LysoGlow84™ Acidic Organelles Probe AG-CMA-1005
 
 
Manufactured in Switzerland 
 

 
Key Research Areas:
INFLAMMASOMES | INFLAMMATION
CANCER | OBESITY & DIABETES 
IMMUNITY | STEM CELL BIOLOGY
   Product Groups:
    ELISA KITS | ANTIBODIES
    PROTEINS | SMALL MOLECULES

 
 
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