NLRP3 Inflammasome Regulation - Small Molecules from AdipoGen

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picture          Immunometabolism &
         Advanced Inflammation

         Research Reagents


Small Molecules in Inflammasome Research
The Widest Range from the Experts


NLRP3 Inflammasome Regulation

 
Selected Inflammasome Activators

Monosodium urate


AG-CR1-3950 (crystals)
AG-CR1-3951 (ready-to-use solution)


Potent NLRP3 inflammasome activator.

Biological Activity Tested!

LIT: Gout-associated uric acid crystals activate the NALP3 inflammasome: F. Martinon, et al.; Nature 440, 237 (2006)

Monosodium Urate Structure

Nigericin


AG-CN2-0020

Potent NLRP3 inflammasome activator.

LIT: Cryopyrin activates the inflammasome in response to toxins and ATP: S. Mariathasan, et al.; Nature 440, 228 (2006)

Nigericin Structure

7BIO


MR-C0020

Induces necrosis and consequently NLRP3 inflammasome activation.

LIT: Cutting edge: Necrosis activates the NLRP3 inflammasome: H. Li, et al.; J. Immunol. 183, 1528 (2009)

7BIO Structure

Selected Inflammasome Inhibitors

MCC950    Newly Introduced


AG-CR1-3615

Potent and selective  NLRP3 inflammasome inhibitor.

LIT: A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases: R.C. Coll, et al.; Nat. Med. 21, 248 (2015)

MCC950 Structure

BAY 11-7082 and Parthenolide
 

AG-CR1-0013
AG-CN2-0455


NLRP3 inflammasome inhibitors, reducing ATPase activity of the NLRP3 inflammasome.

LIT: Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome: C. Juliana, et al.; J. Biol. Chem. 285, 9792 (2010)

BAY 11-7082 and Pathenolide Structure

3-Hydroxybutyric acid


AG-CR1-3616
AG-CR1-3617


New Insights: NLRP3 inflammasome inhibitor.  Prevents K+-efflux and consequently reduces ASC oligomeri-zation and speck formation.

LIT: The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease: Y.H. Youm, et al.; Nat. Med. 21, 263 (2015)

3-Hydroxybutyric acid Structure

Arglabin


AG-CN2-0458

New Insights: NLRP3 inflammasome inhibitor.

LIT: Anti-Inflammatory and antiatherogenic effects of the NLRP3 Inflammasome inhibitor Arglabin in ApoE2.Ki mice fed a high-fat diet: A. Abderrazak, et al.; Circulation 131, 1061 (2015)

Arglabin Structure

Isoliquiritigenin


AG-CN2-0459

New Insights: Inhibits NLRP3-activated ASC oligo-merization. Blocks priming and activation step.

LIT: Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation: H. Honda, et al.; J. Leukoc. Biol. 96, 1087 (2014)

Isoliquiritgenin Structure

Vinpocetine


AG-CN2-0454

NLRP3 inflammasome inhibitor.

LIT: Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells: R.T. Liu, et al.; Exp. Eye Res. 127, 49 (2014)


Vinpocetine Structure

Glyburide (USP)


AG-CR1-3613

NLRP3 inflammasome inhibitor.

LIT: Glyburide inhibits the Cryopyrin/Nalp3 inflammasome: M. Lamkanfi, et al.; J. Cell. Biol. 187, 61 (2009)


Glyburide Structure

Resveratrol


AG-CN2-0033

New Insights: NLRP3 inflammasome inhibitor.

LIT: Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy: Y.P. Chang, et al.; J. Cell Physiol. 230, 1567 (2015)


Resveratrol Structure

Colchicine


AG-CN2-0048

Inhibits acetylated α-tubulin mediated transport of mitochondria and subsequent apposition of ASC on mitochondria to NLRP3 on the endoplasmic reticulum.

LIT: Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome: T. Misawa, et al.; Nat. Immunol. 14, 454 (2013)



Colchicine Structure


 
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