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AdipoGen E-News | March 2012

The Inflammasomes
(In Memory of Jürg Tschopp)



NEW: CASPER-1 & CASPER-2
Unique mAbs to detect activated mouse Caspase-1 by WB

  • Purified mouse monoclonal antibodies (mAbs)
  • CASPER-1 detects endogenous full-length & activated p20 fragment
  • CASPER-2 detects endogenous full-length & activated p10 fragment
  • Best tools to monitor the inflammasome activation
  • Tested and approved by experts in the inflammasome field

Caspase-1 (p10) (mouse), mAb (Casper-2)
Caspase-1 (p20) (mouse), mAb (Casper-1)
Caspase-1 (p20) (mouse), mAb (Casper-1) (Biotin)
  AG-20B-0044-C100
AG-20B-0042-C100
AG-20B-0042B-C100
  100 µg
100 µg
100 µg


Figure: Mouse Caspase-1 (p10) is detected by immunoblotting using anti-Caspase-1 (p10) (mouse), mAb (Casper-2) (Prod. No AG-20B-0044).


Method: Caspase-1 was analyzed by Western blot in supernatants of differentiated bone marrow-derived dendritic cells (BMDCs) from wild-type and caspase-1 knockout mice activated or not by 5μM Nigericin for 30min (Prod. No. AG-CN2-0020). Supernatants (30μl) were separated by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with anti-Caspase-1 (p10) (mouse), mAb (Casper-2) (1μg/ml). Proteins were visualized by a chemiluminescence detection system.



Flagellin - The Source!
AdipoGen offers 2 different qualities of Flagellin.
The standard Flagellin with a purity of >90% (SDS-PAGE) and endotoxin content of <0.1EU/µg. 
"HighPurity" Flagellin with a purity of >95% (SDS-PAGE) and endotoxin content of <0.01EU/µg.


Flagellin (Standard)
Flagellin (High Purity)
MultiPack
  AG-40B-0095-C100
AG-40B-0025-C010
AG-40B-0025-3010
  100 µg
10 µg
3 x 10 µg

New Antibodies from the Bench
NAIP1/2/5 (mouse), mAb (Naipa-1)
NLRP6/NALP6 (human), mAb (Clint-1)
  AG-20B-0045-C100
AG-20B-0046-C100
  100 µg
100 µg

Powerful Tools for Inflammasome Research
NLRP3/NALP3, mAb (Cryo-2)
Asc, pAb (AL177)
The Standards!
  AG-20B-0014-C100
AG-25B-0006-C100
  100 µg
100 µg
NLRP3/NALP3 (mouse), mAb (Cryo-1)
NLRP1/NALP1 (human), pAb (AL176)
NLRP12/NALP12 (human), pAb (AL236)
Nod1 (human), pAb (AL184)
Pyrin (human), pAb (AL196)
AIM2 (human), mAb (3B10)
  AG-20B-0006-C100
AG-25B-0005-C100
AG-25B-0021-C100
AG-25B-0013-C050
AG-25B-0020-C100
AG-20B-0040-C100
  100 µg
100 µg
100 µg
50 µg
100 µg
100 µg
Nigericin . Na
NLRP3/NALP3 inflammasome activator
  AG-CN2-0020-M005
AG-CN2-0020-M025
  5 mg
25 mg
BULK available!
Monosodium urate (crystals)
Monosodium urate (ready-to-use)
NLRP3/NALP3 inflammasome activator
  AG-CR1-3950-M002
AG-CR1-3951-M010
  2 mg
10 mg
BULK available!
BAY 11-7082
Inflammasome inhibitor
  AG-CR1-0013-M010
AG-CR1-0013-M050
  10 mg
50 mg
BULK available!

Ask for discounted BULK quantities!

Visit our Website for a comprehensive overview of Inflammasome Research Reagents.



Inflammasomes Wallchart
 
One year ago on March 22nd, our dear friend
Jürg Tschopp passed away and left a huge gap.
 
In memory and to honor his achievements, AdipoGen dedicates him this new Inflamma-
somes Wallchart.
 
Download: Wallchart

For Ordering please visit: www.adipogen.com
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