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AdipoGen E-News | March 2013

Key and Innovative Tools for
Cancer and Immunology Research




Immune Checkpoint Receptor Proteins


CTLA-4 soluble Fc-fusion proteins enhance T cell cytotoxicity against tumor cells.

CTLA-4 (human):Fc (human) (rec.)
BULK available!
  CHI-HF-210A4   100 µg
500 µg
1 mg
CTLA-4 (mouse):Fc (mouse) (rec.)
BULK available!
  CHI-MF-110A4   100 µg
500 µg
1 mg
CTLA-4 (mouse):Fc (mouse) (rec.) (non-lytic) BULK available!   CHI-MF-120A4   100 µg
500 µg
1 mg


PD-1 soluble Fc-fusion proteins enhance T cell cytotoxicity against tumor cells.

PD-1 (human):Fc (human) (rec.)
BULK available!
  CHI-HF-210PD1   100 µg
PD-1 (human):Fc (human) (rec.) (non-lytic) BULK available!   CHI-HF-220PD1   200 µg


ICOS is required for optimal antitumor response mediated by anti-CTLA-4 treatment.

ICOS (human):Fc (human) (rec.)   CHI-HF-210ICOS   25 µg
100 µg
ICOS (human):Fc (human) (rec.) (non-lytic)   CHI-HF-220ICOS   25 µg
100 µg


LAG-3 Fc-fusion proteins enhance antitumor immune responses. Combinatorial blockade of PD-1 and LAG-3 synergistically reduces the growth of established tumors.

LAG-3 (human):Fc (human) (rec.)   AG-40B-0031   50 µg
LAG-3 (mouse):Fc (mouse) (rec.)
BULK available!
  AG-40B-0039
AG-40B-0039AA
  50 µg
500 µg




TIM-3 receptor blockade in combination with a second immune checkpoint inhibitor enhances antitumor immunity.

Tim-3 (human):Fc (human) (rec.)   CHI-HF-210T3   100 µg
Tim-3 (mouse):Fc (human) (rec.)   CHI-MF-111T3   100 µg



Others

CD40 (human):Fc (human) (rec.)   AG-40B-0083   50 µg
3 x 50 µg
CD134 [OX40] (human):Fc (human) (rec.)   AG-40B-0014   50 µg
3 x 50 µg
CD137 [4-1BB] (human):Fc (human) (rec.)   AG-40B-0060   50 µg
3 x 50 µg
CD137 [4-1BB] (mouse):Fc (human) (rec.)   AG-40A-0025   50 µg




Immune Checkpoint Ligand Proteins

B7-H4 (human):Fc (human) (rec.)   CHI-HF-210B7H4   100 µg
ICOSL (mouse):Fc (mouse) (rec.)   CHI-MF-110B7H2   100 µg
PD-L1 (human):Fc (human) (rec.)   CHI-HF-210PDL1   100 µg
PD-L1 (human):Fc (human) (rec.) (non-lytic)   CHI-HF-220PDL1   100 µg
PD-L1 (mouse):Fc (mouse) (rec.)   CHI-MF-110PDL1   100 µg
PD-L1 (mouse):Fc (mouse) (rec.) (non-lytic)   CHI-MF-120PDL1   100 µg
PD-L2 (human):Fc (human) (rec.) (non-lytic)   CHI-HF-220PDL2   100 µg
MegaCD40L, Soluble (human) (rec.)   AG-40B-0010   10 µg
3 x 10 µg
MegaCD40L, Soluble (mouse) (rec.)   AG-40B-0020   10 µg
3 x 10 µg
MegaCD40L, Soluble (rat) (rec.)   AG-40B-0107   10 µg
3 x 10 µg
MegaOX40L, Soluble (mouse) (rec.)   AG-40B-0029   10 µg
CD137L [4-1BBL], Soluble (human) (rec.)   AG-40A-0198   50 µg
CD137L [4-1BBL], Soluble (mouse) (rec.)   AG-40A-0020   50 µg




Cancer Research Product Flyer

 

 Chimerigen Suppl. Catalog 2013

Targeting Immune Checkpoints Wallchart





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