AdipoGen eTOPIX: Commodity Small Molecules - Highlights - August 2016

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eTOPIX

Commodity Small Molecules for

Cell Selection, Gene Cloning & Expression,
Protease Inhibition, PDE & ATPase Inhibition, 
Tumor Promotion & Microtubule Modulation


From the Manufacturer - BULK Available!



 



Cell Selective Agents      
 
G418 . sulfate (>98%) AG-CN2-0030


Antibiotic. Cytotoxic to prokaryotic and eukaryotic cells by inhibiting the protein synthesis. Widely employed in the selection of eukaryotic expression vectors.

LIT: J.C. Morris, et al.; J. Biol. Chem. 271, 15468 (1996) | M. Kung, et al.; FEBS Lett. 409, 333 (1997)


 

G418 . sulfate
 
Also Available:   Puromycin . 2HCl (>98%) AG-CN2-0078

 

Gene Cloning Tools
 
IPTG (animal-free, dioxane-free) (>99%) AG-CC1-0002


Molecular biology reagent. β-galactosidase activity inducer in several bacteria by binding and inhibiting the lac repressor. Used in gene cloning together with X-Gal (Prod. No. AG-CC1-0003), in a technique called blue/white screening.

LIT: Molecular Cloning: A Laboratory Manual 3rd Edition: J. Sambrook & D. Russell; Cold Spring Harbor Laboratory Press (2001)

IPTG
 
Also Available:   X-Gal (>99%) AG-CC1-0003

 

Potent Tumor Promoters                    Original Manufacturer!
 
Phorbol 12-myristate 13-acetate [PMA/TPA] (>98%) AG-CN2-0010


Most commonly-used phorbol ester. Potent mouse skin tumor promoter. Binds to and activates protein kinase C (PKC) at nM concentrations.

LIT: P.M. Blumberg; Crit. Rev. Toxicol. 8, 153 (1980) | P.M. Blumberg; Crit. Rev. Toxicol. 8, 199 (1981) | G. Fürstenberger, et al.; PNAS 78, 7722 (1981)

 

PMA
 
Also Available:   Thapsigargin (high purity) (>98%) AG-CN2-0003

 

Gene Expression Tools
 
Anhydrotetracycline . HCl (>98%) CDX-A0197


Effector of tetracycline-dependent gene expression in bacterial expression systems. Powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.

LIT: A. Kamionka, et al.; Nucleic Acids Res. 32, 842 (2004) | M. Resch, et al.; Nucleic Acids Res. 36, 4390 (2008)

Anhydrotetracycline HCl
 
Also Available:   Ponasterone (>95%) AG-CN2-0053

 

Protease Inhibitors - Standard Protein Purification Tools
 
Leupeptin . hemisulfate (>97%) AG-CP3-7000


Potent, competitive and reversible cysteine, serine and threonine protease inhibitor. Widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.

 

Leupeptin . hemisulfate
 
Also Available:   Amastatin, Antipain, Pepstatin A, Pefabloc® SC

 

Potent H+-ATPase Inhibitors              Original Manufacturer!
 
Bafilomycin A1 (high purity) (>98%) BVT-0252


Macrolide antibiotic. Specific vacuolar-type H+-ATPase inhibitor. Distinguishes among different types of ATPases. Inhibitor of endosomal, lysosomal and vacuolar acidification. 

LIT: T. Yoshimori, et al.; J. Biol. Chem. 266, 17707 (1991)

 

Bafilomycin A1
 
Also Available:   Concanamycin A (high purity) (>98%) BVT-0237

 

cAMP & cGMP Phosphodiesterase Inhibitor  The Source!
 
IBMX [3-Isobutyl 1-methylxanthine] (>99%) AG-CR1-3512


Cell permeable, competitive, non-specific cAMP and cGMP phosphodiesterase inhibitor, which consequently increases cAMP levels that activate PKA. Used to enhance differentiation of 3T3-L1 cells and neuronal cells.

LIT: M.L. Elks & V.C. Manganiello; J. Cell Physiol. 124, 191 (1985) | C. Tomes, et al.; Cell Signal. 5, 615 (1993) | A. Lange, et al.; Lung Cancer 74, 178 (2011)

IBMX

 

Panel of Microtubule Modulators      Original Manufacturer!
 
Jasplakinolide (high purity) (>98%) AG-CN2-0037


Cell permeable, non-fluorescent F-actin probe. Potent inducer of actin polymerization & stabilization. Antiproliferative and anticancer compound. Apoptosis enhancer/inducer. 

LIT: F. Lázaro-Diéguez, et al.; Autophagy 4, 717 (2008) | A. Holzinger; Methods Mol. Biol. 586, 71 (2009)

 

Jasplakinolide
 
Also Available:   Latrunculin A, Latrunculin B, Paclitaxel [Taxol]

 
Brochure "Small Molecules Highlights 2016"
 
Focus:

Synthetic Small Molecules
Unique Natural Products
Rare Antibiotics

Includes Products from:

AdipoGen Life Sciences
BioViotica
Chemodex
Innaxon

 

Download Product Brochure


Small Molecule Brochure 2016

 
Key Research Areas:
INFLAMMASOMES | INFLAMMATION
CANCER | OBESITY & DIABETES 
IMMUNITY | STEM CELL BIOLOGY
IMMUNO-ONCOLOGY
   Product Groups:
    ELISA KITS | ANTIBODIES
    PROTEINS | SMALL MOLECULES
    FLUORESCENT DYES & PROBES

 
 
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