AdipoGen eTOPIX: New Netrin-1 Blocking Antibody for Antitumor Research - July 2016

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eTOPIX

Netrin-1 [NTN-1]
Multifunctional Dependence Receptor Ligand
A Novel Therapeutic Target
 
  • Survival Factor in Multiple Types of Cancers
  • Key Axon Guidance Factor Important for Neuronal Development
  • Cardiovascular/Atherosclerosis Target
  • Pro-/Anti-Angiogenic Factor
  • Important for Liver Protection, Tissue Homeostasis & Regeneration
  • Regulator of Somatic Cell Reprogramming & Pluripotency Maintenance
  • Enhances Infectivity of Oncogenic HCV

 
 

NEW Potent Netrin-1 Blocking Antibody
 
anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative-free) AG-27B-0018PF
Negative Control Antibody
anti-Netrin-1 (human), mAb (rec.) (H4) (preservative-free) AG-27B-0020PF
 
 


Blocking of tumor growth in vivo. Method: Tumor cells (OCI-Ly3) were implanted in SCID mice by subcutaneous injection of 3x106 cells in 100µl of PBS. When tumors reached 150mm3, mice received intraperitoneal injections of blocking anti-Netrin-1 mAb (2F5) at 20 mg/kg or an equal volume of the antibody control anti-Netrin-1, mAb (rec.) (H4) every two days. Tumor growth rates from the beginning of treatment are shown.
 

Raptinal


LATEST INSIGHT


L. Broutier, et al. (2016) and M.-L. Plissonnier, et al. (2016) recently reported the use of AdipoGen's Netrin-1 mAb (2F5) (AG-27B-0018PF) to block tumor growth in B cell lymphoma xenografts in vivo and in vitro, and to block HCV infectivity and propagation in vitro in an EGFR-dependent process, respectively.

LIT: Targeting netrin-1/DCC interaction in diffuse large B-cell and mantle cell lymphomas: T. Broutier, et al.; EMBO Mol. Med. 8, 96 (2016) | Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus: M.L. Plissonnier, et al.; PLoS Biol. 14, e1002421 (2016)


 

Functional Antibodies Catalog


Validated PANEL of Recombinant Netrin-1 Proteins


Biological Active Human Netrin-1 - BULK Available
  • Full Biological Activity
  • Unique Improved Formulation
    • Higher Protein Stability & Activity
    • Does not Aggregate – Does not Precipitate
    • Contains no BSA
  • Cross-reacts with Human and Mouse Receptors

 
Netrin-1 (human):Fc (human) (rec.) AG-40B-0075
Netrin-1 (human) (rec.) AG-40B-0040


Recombinant Netrin-1 Receptor Protein
 
UNC5B (human):Fc (human) (rec.) AG-40B-0037
 
 
Netrin-1 - Generation of iPSC


LATEST INSIGHT


D. Ozmadenci, et al. (2015) identified Netrin-1 as the 5th Element of classical iPS cell factors. Recombinant human Netrin-1 from AdipoGen (AG-40A-0075 and AG-40A-0040) was used together with the original factors Oct4, Sox2, Klf4 and c-Myc to produce 15 times more induced pluripotent stems cells (iPSCs) under specific culture conditions than without Netrin-1.

LIT: Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance: D. Ozmadenci, et al.; Nat. Commun. 6, ID7398 (2015)

 


 
Key Research Areas:
INFLAMMASOMES | INFLAMMATION
CANCER | OBESITY & DIABETES 
IMMUNITY | STEM CELL BIOLOGY
IMMUNO-ONCOLOGY
   Product Groups:
    ELISA KITS | ANTIBODIES
    PROTEINS | SMALL MOLECULES
    FLUORESCENT DYES & PROBES

 
 
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