Potent Immuno-Oncology Reagents from AdipoGen

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picture          Immunometabolism &
         Advanced Inflammation

         Research Reagents


Potent Immuno-Oncology Proteins

Biologically Active IDO1, CTLA-4, PD-1, B7-H4, LAG-3, Tim-3


Highly Active IDO Enzyme & Inhibitor


 


HIGHLIGHTS IDO1 Enzyme & Key Inhibitor
 
NEW IDO1 (human) Enzyme+Inhibitor Set AG-44B-0006
IDO1 (human) (rec.) (His) (highly active) AG-40B-0161

MMG-0358 Potent Triazole IDO1 Inhibitor AG-CR1-3630

Shows IC50 values of 2nM in a cellular assay on mIDO1, 80nM in a cellular assay on hIDO1, 330nM in an enzymatic assay on hIDO1 at pH 6.5, and 71nM in an enzymatic assay on hIDO1 at pH 7.4. Active in vivo.

LIT: Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition: U.F. Roehrig, et al.; J. Med. Chem. 55, 5270 (2012)

MMG-0358 Structure


HIGHLIGHTS  Active Immune Checkpoint Proteins
 
B7-H4 (human):Fc (human) (rec.) CHI-HF-210B7H4
B7-H4 (mouse):Fc (mouse) (rec.) CHI-MF-110B7H4
CTLA-4 (human):Fc (human) (rec.) CHI-HF-210A4
CTLA-4 (human):Fc (human) (rec.) (non-lytic) CHI-HF-220A4
CTLA-4 (human):Fc (mouse) (rec.) CHI-HF-211A4
CTLA-4 (mouse):Fc (mouse) (rec.) CHI-MF-110A4
CTLA-4 (mouse):Fc (mouse) (rec.) (non-lytic) CHI-MF-120A4
PD-1 (human):Fc (human) (rec.) CHI-HF-210PD1
PD-1 (human):Fc (human) (rec.) (non-lytic) CHI-HF-220PD1
PD-1 (mouse):Fc (mouse) (rec.) CHI-MF-110PD1
PD-L1/B7-H1 (human):Fc (human) (rec.) CHI-HF-210PDL1
PD-L1/B7-H1 (human):Fc (human) (rec.) (non-lytic) CHI-HF-220PDL1
PD-L1/B7-H1 (mouse):Fc (mouse) (rec.) CHI-MF-110PDL1
PD-L1/B7-H1 (mouse):Fc (mouse) (rec.) (non-lytic) CHI-MF-120PDL1
PD-L2 (human):Fc (human) (rec.) CHI-HF-210PDL2
PD-L2 (human):Fc (human) (rec.) (non-lytic) CHI-HF-220PDL2
PD-L2 (mouse):Fc (mouse) (rec.) CHI-MF-110PDL2
 

HIGHLIGHTS  LAG-3 in Cancer Immunotherapy
 
Functional Blocking Antibodies
LAG-3 (human), mAb (blocking) (17B4) AG-20B-0012
LAG-3 (human), mAb (blocking) (17B4) (preservative free) AG-20B-0012PF
LAG-3, mAb (blocking) (11E3) AG-20B-0011
LAG-3, mAb (blocking) (11E3) (preservative free) AG-20B-0011PF
Biologically Active Proteins
LAG-3 (human):Fc (human) (rec.) AG-40B-0031
LAG-3 (mouse):Fc (mouse) (rec.) AG-40B-0039
 

HIGHLIGHTS  T-cell Immunoglobulin and Mucin Domain
 
Tim-3 (human):Fc (human) (rec.) CHI-HF-210T3
Tim-3 (mouse):Fc (mouse) (rec.) CHI-MF-110T3
Click for a Full Panel of Tim Proteins
 
 
HIGHLIGHTS CD1d Ligand Antitumor Adjuvants
 
α-Galactosylceramide Potent NKT Cell stimulator AG-CN2-0013

Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells. Potent antitumor compound.

LIT:
Combination of the toll like receptor agonist and α-Galactosylceramide as an efficient adjuvant for cancer vaccine: F. Gableh, et al.; J. Biomed. Sci. 23, 16 (2016)

alpha-Galactosylceramide Structure


For a Full Panel see our
CD1d Ligand Flyer!









 



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Key Research Areas:
INFLAMMASOMES | INFLAMMATION
CANCER | OBESITY & DIABETES 
IMMUNITY | STEM CELL BIOLOGY
   Product Groups:
    ELISA KITS | ANTIBODIES
    PROTEINS | SMALL MOLECULES

 
 
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